3.0
Summary
| Name |  RNF125
|
| Full Name | E3 ubiquitin-protein ligase RNF125 |
| Synonyms | RING finger protein 125, T-cell RING activation protein 1, TRAC-1 | |
| Primary ID | Q96EQ8 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:26027934, PubMed:26471729, PubMed:25591766, PubMed:27411375). Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation (PubMed:17460044, PubMed:26471729). Mediates ubiquitination and subsequent degradation of p53/TP53 (PubMed:25591766). Mediates ubiquitination and subsequent degradation of JAK1 (PubMed:26027934). Acts as a positive regulator of T-cell activation (PubMed:15843525). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | Ub:E2 | up-regulates activity 
ubiquitination
|
RNF125 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNF125 | down-regulates quantity by destabilization 
polyubiquitination
|
IFIH1 | 0.643 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNF125 | down-regulates quantity by destabilization
polyubiquitination
|
DDX58 | 0.658 |
| Publications: | 1 | Organism: | Homo Sapiens | |