Summary

Name PELI1
Full Name E3 ubiquitin-protein ligase pellino homolog 1
Synonyms Pellino-1, Pellino-related intracellular-signaling molecule | PRISM
Primary ID Q96FA3
Links - -
Type protein
Relations 8
Pathways IL1 Receptor
Function E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation PELI1 0.85
Publications: 6 Organism: Homo Sapiens
Pathways:IL1 Receptor
+ up-regulates quantity by expression img/direct-activation.png ubiquitination IRAK1 0.85
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Receptor
+ up-regulates img/direct-activation.png binding PELI1 0.42
Publications: 1 Organism: Homo Sapiens