| Name
|
 MED8
|
| Full Name |
Mediator of RNA polymerase II transcription subunit 8 |
| Synonyms |
Activator-recruited cofactor 32 kDa component, ARC32, Mediator complex subunit 8 | |
| Primary ID |
Q96G25 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins. |
3.0
binding