Summary

Name CENPN
Full Name Centromere protein N
Synonyms CENP-N, Interphase centromere complex protein 32 | C16orf60, ICEN32
Primary ID Q96H22
Links - -
Type protein
Relations 2
Function Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding CCAN complex 0.717
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CENP-A nucleosome 0.899
Publications: 1 Organism: Homo Sapiens