3.0
Summary
| Name |  CENPN
|
| Full Name | Centromere protein N |
| Synonyms | CENP-N, Interphase centromere complex protein 32 | C16orf60, ICEN32 |
| Primary ID | Q96H22 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. |
Viewer
Search Tools
Refine search:
- by mechanism
- by effect
- by organism:
- by tissue:
- by cell-line
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CENPN | form complex 
binding
|
CCAN complex | 0.716 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CENPN | up-regulates activity 
binding
|
CENP-A nucleosome | 0.9 |
| Publications: | 1 | Organism: | Homo Sapiens | |