Summary

Name RITA1
Full Name RBPJ-interacting and tubulin-associated protein 1
Synonyms RBPJ-interacting and tubulin-associated protein | C12orf52, RITA
Primary ID Q96K30
Links - -
Type protein
Relations 1
Function Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

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Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png binding RBPJ
Publications: 1 Organism: Homo Sapiens