4.0
Summary
| Name |  RBPJView Modifications |
| Full Name | Recombining binding protein suppressor of hairless |
| Synonyms | CBF-1, J kappa-recombination signal-binding protein, RBP-J kappa, RBP-J, RBP-JK, Renal carcinoma antigen NY-REN-30 | IGKJRB, IGKJRB1, RBPJK, RBPSUH |
| Primary ID | Q06330 |
| Links |  -  -  |
| Type | protein |
| Relations | 27 |
| Pathways | Satellite: NOTCH |
| Function | Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAPK14 | down-regulates quantity by destabilization 
phosphorylation
|
RBPJ | 0.246 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HES1 | down-regulates
binding
|
RBPJ | 0.619 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HEY1 | down-regulates
binding
|
RBPJ | 0.676 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RBPJ | down-regulates quantity by repression 
transcriptional regulation
|
NOTCH | 0.952 |
| Publications: | 1 | |||
| + | RBPJ | form complex 
binding
|
RBPJ/NOTCH | 0.952 |
| Publications: | 3 | Organism: | Homo Sapiens, | |
| + | MAPK8IP1 | down-regulates
binding
|
RBPJ | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NOTCH3 | up-regulates 
binding
|
RBPJ | 0.863 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RITA1 | down-regulates
binding
|
RBPJ | 0.409 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SPEN | down-regulates
binding
|
RBPJ | 0.717 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RBPJ | up-regulates quantity by expression
transcriptional regulation
|
CDKN1A | 0.305 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | RBPJ | up-regulates
binding
|
MAML3 | 0.88 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RBPJ | up-regulates
binding
|
GTF2A2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RBPJ | up-regulates
binding
|
CIR1 | 0.68 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RBPJ | up-regulates quantity by expression
binding
|
HES1 | 0.619 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RBPJ | up-regulates
binding
|
MAML2 | 0.873 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RBPJ | up-regulates quantity by expression 
transcriptional regulation
|
CDKN1A | 0.305 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NOTCH1 | up-regulates
binding
|
RBPJ | 0.952 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FHL1 | down-regulates
binding
|
RBPJ | 0.629 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RBPJ | up-regulates
binding
|
DUSP1 | 0.248 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | MAML1 | up-regulates
binding
|
RBPJ | 0.878 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FOXC1 | up-regulates
binding
|
RBPJ | 0.274 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RBPJ | up-regulates
binding
|
PAX7 | 0.358 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RBPJ | down-regulates quantity by repression
transcriptional regulation
|
NFKB2 | 0.265 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RBPJ | up-regulates quantity
transcriptional regulation
|
HES1 | 0.619 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | DVL2 | down-regulates activity
binding
|
RBPJ | 0.266 |
| Publications: | 1 | Organism: | Cricetulus Griseus | |