Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273607 |
Ser318 |
QGRESKGsPKKRLDV |
Rattus norvegicus |
Neuron |
pmid |
sentence |
21487013 |
We show that scapinin is phosphorylated at a highly conserved site in the central region of the protein (Ser-277) by Cdk5 in vitro. Expression of a scapinin phospho-mimetic mutant (S277D) restored normal axon elongation without affecting actin binding. Instead, phosphorylated scapinin was sequestered in the cytoplasm of neurons and away from the axon. |
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