| + |
LCK | up-regulates 
phosphorylation
|
SIGLEC10 |
0.263 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112491 |
Tyr597 |
RHSTILDyINVVPTA |
Homo sapiens |
|
| pmid |
sentence |
| 11733002 |
These results suggest that the tyrosines at positions 597 and 667, contained within itim-like motifs, are likely targets of phosphorylation by several classes of signaling molecules, including lck, jak3, and emt. The tyrosine located at position y691 was also contributing to the phosphorylation of the wild-type siglec tail by lck and jak3 kinases. Y597 and y667 are likely involved in intracellular signaling |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112495 |
Tyr667 |
ESQEELHyATLNFPG |
Homo sapiens |
|
| pmid |
sentence |
| 11733002 |
These results suggest that the tyrosines at positions 597 and 667, contained within itim-like motifs, are likely targets of phosphorylation by several classes of signaling molecules, including lck, jak3, and emt. The tyrosine located at position y691 was also contributing to the phosphorylation of the wild-type siglec tail by lck and jak3 kinases. Phosphorylation of the tyrosine located at position 667 in an itim motif appears to be necessary for the recruitment of shp-1 and partial recruitment of shp-2 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ITK | up-regulates
phosphorylation
|
SIGLEC10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112471 |
Tyr597 |
RHSTILDyINVVPTA |
Homo sapiens |
|
| pmid |
sentence |
| 11733002 |
These results suggest that the tyrosines at positions 597 and 667, contained within itim-like motifs, are likely targets of phosphorylation by several classes of signaling molecules, including lck, jak3, and emt. The tyrosine located at position y691 was also contributing to the phosphorylation of the wild-type siglec tail by lck and jak3 kinases. Y597 and y667 are likely involved in intracellular signaling |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112475 |
Tyr667 |
ESQEELHyATLNFPG |
Homo sapiens |
|
| pmid |
sentence |
| 11733002 |
These results suggest that the tyrosines at positions 597 and 667, contained within itim-like motifs, are likely targets of phosphorylation by several classes of signaling molecules, including lck, jak3, and emt. The tyrosine located at position y691 was also contributing to the phosphorylation of the wild-type siglec tail by lck and jak3 kinases. Phosphorylation of the tyrosine located at position 667 in an itim motif appears to be necessary for the recruitment of shp-1 and partial recruitment of shp-2 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
JAK3 | up-regulates
phosphorylation
|
SIGLEC10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112479 |
Tyr597 |
RHSTILDyINVVPTA |
Homo sapiens |
|
| pmid |
sentence |
| 11733002 |
These results suggest that the tyrosines at positions 597 and 667, contained within itim-like motifs, are likely targets of phosphorylation by several classes of signaling molecules, including lck, jak3, and emt. The tyrosine located at position y691 was also contributing to the phosphorylation of the wild-type siglec tail by lck and jak3 kinases. Y597 and y667 are likely involved in intracellular signaling |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112483 |
Tyr667 |
ESQEELHyATLNFPG |
Homo sapiens |
|
| pmid |
sentence |
| 11733002 |
These results suggest that the tyrosines at positions 597 and 667, contained within itim-like motifs, are likely targets of phosphorylation by several classes of signaling molecules, including lck, jak3, and emt. The tyrosine located at position y691 was also contributing to the phosphorylation of the wild-type siglec tail by lck and jak3 kinases. Phosphorylation of the tyrosine located at position 667 in an itim motif appears to be necessary for the recruitment of shp-1 and partial recruitment of shp-2 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
JAK3 |
phosphorylation
|
SIGLEC10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112487 |
Tyr691 |
PKGTQADyAEVKFQ |
Homo sapiens |
|
| pmid |
sentence |
| 11733002 |
These results suggest that the tyrosines at positions 597 and 667, contained within itim-like motifs, are likely targets of phosphorylation by several classes of signaling molecules, including lck, jak3, and emt. The tyrosine located at position y691 was also contributing to the phosphorylation of the wild-type siglec tail by lck and jak3 kinases. however, it is not clear whether y691 is capable of binding sap or a similar protein. Future studies will attempt to elucidate the signaling activities associated with y691 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LCK |
phosphorylation
|
SIGLEC10 |
0.263 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112499 |
Tyr691 |
PKGTQADyAEVKFQ |
Homo sapiens |
|
| pmid |
sentence |
| 11733002 |
These results suggest that the tyrosines at positions 597 and 667, contained within itim-like motifs, are likely targets of phosphorylation by several classes of signaling molecules, including lck, jak3, and emt. The tyrosine located at position y691 was also contributing to the phosphorylation of the wild-type siglec tail by lck and jak3 kinases. however, it is not clear whether y691 is capable of binding sap or a similar protein. Future studies will attempt to elucidate the signaling activities associated with y691 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SIGLEC10
- 
- 