| + |
MAPK1 | up-regulates 
phosphorylation
|
BMF |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195471 |
Ser74 |
DKATQTLsPASPSQG |
Homo sapiens |
Lymphoma Cell |
| pmid |
sentence |
| 22258404 |
Phosphomimetic mutation of this site (s74d) moderately enhanced bmf apoptotic activity in vivo.22 here, we demonstrate a previously unrecognized mode of regulation of bmf. We show that b-raf-mek-erk2 signaling regulates bmf phosphorylation at serine 74 and serine 77. Phosphorylation of serine 77 downregulates the pro-apoptotic activity of bmf. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195475 |
Ser77 |
TQTLSPAsPSQGVML |
Homo sapiens |
Lymphoma Cell |
| pmid |
sentence |
| 22258404 |
Phosphomimetic mutation of this site (s74d) moderately enhanced bmf apoptotic activity in vivo.22 here, we demonstrate a previously unrecognized mode of regulation of bmf. We show that b-raf-mek-erk2 signaling regulates bmf phosphorylation at serine 74 and serine 77. Phosphorylation of serine 77 downregulates the pro-apoptotic activity of bmf. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK8 | up-regulates activity
phosphorylation
|
BMF |
0.677 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250116 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12591950 |
Activated JNK causes BimL and Bmf phosphorylation in vivo. It is known that UV radiation causes the release of Bim and Bmf from dynein and myosin V motor complexes and that these proteins cause Bax/Bak-dependent apoptosis . The results of this study demonstrate that JNK can engage this apoptotic pathway by phosphorylation of BH3-only proteins, including Bim and Bmf. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
BMF
- 
- 