| Name
|
 C10orf90
|
| Full Name |
(E2-independent) E3 ubiquitin-conjugating enzyme FATS |
| Synonyms |
EC 2.3.2.-, Centrosomal protein C10orf90, E2/E3 hybrid ubiquitin-protein ligase FATS, Fragile-site associated tumor suppressor homolog, FATS | FATS |
| Primary ID |
Q96M02 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Function |
Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21 (By similarity). May have a role in the assembly of primary cilia (Probable). {ECO:0000250|UniProtKB:D2J0Y4, ECO:0000305|PubMed:20844083}. |
3.0
polyubiquitination