Summary

Name CEP63
Full Name Centrosomal protein of 63 kDa
Synonyms Cep63 |
Primary ID Q96MT8
Links - -
Type protein
Relations 2
Function Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes (PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398).

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Relations

Regulator Mechanism target score ℹ
+ CEP63up-regulates activity img/direct-activation.png relocalization CDK2 0.382
Publications: 1 Organism: Homo Sapiens
+ CDK5RAP2up-regulates activity img/direct-activation.png relocalization CEP63 0.68
Publications: 1 Organism: Homo Sapiens