Summary

Name DOCK7
Full Name Dedicator of cytokinesis protein 7
Synonyms DOCK7_HUMAN | KIAA1771
Primary ID Q96N67
Links - -
Type protein
Relations 4
Function Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation DOCK7 0.509
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DOCK7 0.393
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.52
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.725
Publications: 1 Organism: Mus Musculus