Relation Results

Summary

Name SLC46A1
Full Name Proton-coupled folate transporter
Synonyms G21, Heme carrier protein 1, PCFT/HCP1, Solute carrier family 46 member 1 | HCP1, PCFT
Primary ID Q96NT5
Links - -
Type protein
Relations 3
Function Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme ...
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Type: Score: Layout: SPV 
0.80.80.339SLC46A1hemedihydrofolate(2-)NRF1

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Relations
Regulator
Mechanism
target
score ℹ
+ SLC46A1up-regulates quantity img/direct-activation.png relocalization heme 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268265 Homo sapiens Hepatocyte
pmid sentence
SLC46A1 contributes to hepatic iron metabolism by importing heme in hepatocytes.
Publications: 1 Organism: Homo Sapiens
+ SLC46A1up-regulates quantity img/direct-activation.png relocalization dihydrofolate(2-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268264 Homo sapiens Hepatocyte
pmid sentence
However, the current study establishes that a major function of this gene product is proton-coupled folate transport required for folate homeostasis in man, and we have thus amended the name to PCFT/HCP1.
Publications: 1 Organism: Homo Sapiens
+ NRF1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SLC46A1 0.339
Identifier Residue Sequence Organism Cell Line
SIGNOR-254884 Homo sapiens
pmid sentence
Overexpression of NRF-1 or a constitutively active NRF-1 VP-16 construct resulted in increased reporter activity and PCFT mRNA levels. These novel findings identify NRF-1 as a major inducible transcriptional regulator of PCFT gene expression.
Publications: 1 Organism: Homo Sapiens
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