Relation Results

Summary

Name NRF1
Full Name Nuclear respiratory factor 1
Synonyms NRF-1, Alpha palindromic-binding protein, Alpha-pal
Primary ID Q16656
Links - -
Type protein
Relations 13
Function Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cel ...
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Type: Score: Layout: SPV 
0.2660.5560.20.20.20.3390.7090.290.339NRF1ENOX1TFB2MPRKAA1BRK1RETREG3SLC46A1PPARGC1AFMR1SPAST

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Relations
Regulator
Mechanism
target
score ℹ
+ NRF1up-regulates img/indirect-activation.png ENOX1 0.266
Identifier Residue Sequence Organism Cell Line
SIGNOR-261488 Homo sapiens IMR-32 Cell
pmid sentence
We found that NRF-1 positively regulates FAM134C and ENOX1, but negatively regulates C3orf10 in human neuroblastoma IMR-32 cells and primary rat cortical neurons. In IMR-32 cells, FAM134C positively regulates and C3orf10 negatively regulates neurite outgrowth, but ENOX1 plays no role in neurite outgrowth regulation. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-261451 Homo sapiens IMR-32 Cell
pmid sentence
We found that NRF-1 positively regulates FAM134C and ENOX1, but negatively regulates C3orf10 in human neuroblastoma IMR-32 cells and primary rat cortical neurons. In IMR-32 cells, FAM134C positively regulates and C3orf10 negatively regulates neurite outgrowth, but ENOX1 plays no role in neurite outgrowth regulation. 
Publications: 2 Organism: Homo Sapiens
+ NRF1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TFB2M 0.556
Identifier Residue Sequence Organism Cell Line
SIGNOR-268999 Homo sapiens
pmid sentence
Here, we establish that the expression of human TFB1M and TFB2M promoters is governed by nuclear respiratory factors (NRF-1 and NRF-2), key transcription factors implicated in mitochondrial biogenesis. In addition, we show that NRF recognition sites within both TFB promoters are required for maximal trans activation by the PGC-1 family coactivators, PGC-1alpha and PRC
Identifier Residue Sequence Organism Cell Line
SIGNOR-268997 Homo sapiens
pmid sentence
Here, we establish that the expression of human TFB1M and TFB2M promoters is governed by nuclear respiratory factors (NRF-1 and NRF-2), key transcription factors implicated in mitochondrial biogenesis. In addition, we show that NRF recognition sites within both TFB promoters are required for maximal trans activation by the PGC-1 family coactivators, PGC-1alpha and PRC
Publications: 2 Organism: Homo Sapiens
+ PRKAA1up-regulates img/indirect-activation.png NRF1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-130076 Homo sapiens
pmid sentence
In muscle, it causes increased dna binding by the transcription factors nrf1 (bergeron et al., 2001) and mef2 (zheng et al., 2001), which may be involved in regulation of mitochondrial genes and glut4, respectively.
Publications: 1 Organism: Homo Sapiens
+ NRF1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BRK1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-261369 Homo sapiens
pmid sentence
We found that NRF-1 positively regulates FAM134C and ENOX1, but negatively regulates C3orf10 in human neuroblastoma IMR-32 cells and primary rat cortical neurons.
Publications: 1 Organism: Homo Sapiens
+ NRF1up-regulates img/indirect-activation.png RETREG3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-261489 Homo sapiens IMR-32 Cell
pmid sentence
We found that NRF-1 positively regulates FAM134C and ENOX1, but negatively regulates C3orf10 in human neuroblastoma IMR-32 cells and primary rat cortical neurons. In IMR-32 cells, FAM134C positively regulates and C3orf10 negatively regulates neurite outgrowth, but ENOX1 plays no role in neurite outgrowth regulation. 
Publications: 1 Organism: Homo Sapiens
+ NRF1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ENOX1 0.266
Identifier Residue Sequence Organism Cell Line
SIGNOR-261368 Homo sapiens
pmid sentence
We found that NRF-1 positively regulates FAM134C and ENOX1, but negatively regulates C3orf10 in human neuroblastoma IMR-32 cells and primary rat cortical neurons.
Publications: 1 Organism: Homo Sapiens
+ NRF1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SLC46A1 0.339
Identifier Residue Sequence Organism Cell Line
SIGNOR-254884 Homo sapiens
pmid sentence
Overexpression of NRF-1 or a constitutively active NRF-1 VP-16 construct resulted in increased reporter activity and PCFT mRNA levels. These novel findings identify NRF-1 as a major inducible transcriptional regulator of PCFT gene expression.
Publications: 1 Organism: Homo Sapiens
+ PPARGC1Aup-regulates activity img/indirect-activation.png NRF1 0.709
Identifier Residue Sequence Organism Cell Line
SIGNOR-253391 Homo sapiens
pmid sentence
PGC-1 family transcriptional coactivators enhance the activities of the nuclear respiratory factors NRF1 and NRF2, which induce transactivation of many genes encoding mitochondria-specific proteins involved in respiratory chain, mitochondrial DNA transcription/replication and protein import/assembly
Publications: 1 Organism: Homo Sapiens
+ NRF1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FMR1 0.29
Identifier Residue Sequence Organism Cell Line
SIGNOR-254881 Homo sapiens
pmid sentence
We have also shown that USF1, USF2, and alpha-Pal/Nrf-1 are the major transcription factors that bind the promoter in brain and testis extracts and suggest that elevated levels of these factors account in part for elevated FMR1 expression in these organs.
Publications: 1 Organism: Homo Sapiens
Tissue: Testis, Brain
+ NRF1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RETREG3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-261367 Homo sapiens
pmid sentence
We found that NRF-1 positively regulates FAM134C and ENOX1, but negatively regulates C3orf10 in human neuroblastoma IMR-32 cells and primary rat cortical neurons.
Publications: 1 Organism: Homo Sapiens
+ NRF1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SPAST 0.339
Identifier Residue Sequence Organism Cell Line
SIGNOR-254885 Homo sapiens
pmid sentence
we demonstrate that SPAST transcription is positively regulated by NRF1 and SOX11.
Publications: 1 Organism: Homo Sapiens
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