| + |
COL21A1 | up-regulates activity 
binding
|
A2/b1 integrin |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272347 |
|
|
|
|
| pmid |
sentence |
| 35267698 |
Integrins constitute a major group of receptors for extracellular matrix components, including collagens.|Among the four types, the signaling mechanism of α1β1 and α2β1 integrins has especially been reported. These integrins bind to both collagen types I and IV; however, their affinities differ: α1β1 has a higher affinity for collagen type IV, while α2β1 preferentially binds to collagen type I [13,23]. |
|
| Publications: |
1 |
| + |
COL21A1 | up-regulates activity
binding
|
DDR2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272343 |
|
|
Homo sapiens |
HT-1080 Cell |
| pmid |
sentence |
| 17318226 |
The Discoidin Domain Receptors (DDRs) constitute a unique set of receptor tyrosine kinases that signal in response to collagen.|Consistent with this view128, we showed that ectopic expression of DDR1b or DDR2 in HT1080 cells elicited a potent growth inhibitory effect only when the cells were cultured on 2D or 3D COL1 matrices, in agreement with previous studies in melanoma48, breast cancer76,78, and lung cancer cells74,75. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
COL21A1 | up-regulates activity
binding
|
DDR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272341 |
|
|
Homo sapiens |
HT-1080 Cell |
| pmid |
sentence |
| 17318226 |
The Discoidin Domain Receptors (DDRs) constitute a unique set of receptor tyrosine kinases that signal in response to collagen.|Consistent with this view128, we showed that ectopic expression of DDR1b or DDR2 in HT1080 cells elicited a potent growth inhibitory effect only when the cells were cultured on 2D or 3D COL1 matrices, in agreement with previous studies in melanoma48, breast cancer76,78, and lung cancer cells74,75. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
COL21A1
- 
- 