Summary

Name DDR2
Full Name Discoidin domain-containing receptor 2
Synonyms Discoidin domain receptor 2, CD167 antigen-like family member B, Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Tyrosine-protein kinase TYRO10 | NTRKR3, TKT, TYRO10
Primary ID Q16832
Links - -
Type protein
Relations 7
Inhibitors regorafenib
Function Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416). It functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ SRCup-regulates img/direct-activation.png phosphorylation DDR2 0.388
Publications: 3 Organism: Homo Sapiens
+ DDR2up-regulates img/direct-activation.png binding SHC1 0.402
Publications: 1 Organism: Homo Sapiens
+ COL1A1up-regulates activity img/direct-activation.png binding DDR2 0.434
Publications: 1 Organism: Homo Sapiens
+ COL21A1up-regulates activity img/direct-activation.png binding DDR2 0.2
Publications: 1 Organism: Homo Sapiens
+ regorafenibdown-regulates activity img/direct_inhibition.png chemical inhibition DDR2 0.8
Publications: 1 Organism: Homo Sapiens