| + |
RCHY1 | down-regulates activity 
monoubiquitination
|
POLH |
0.563 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272730 |
Lys682 |
SAVSHQGkRNPKSPL |
Homo sapiens |
|
| pmid |
sentence |
| 21791603 |
Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis. Specifically, we show that Pirh2, a target of the p53 tumor suppressor, monoubiquitinates PolH at one of multiple lysine residues.we show that monoubiquitination of PolH alters the ability of PolH to translocate to replication foci for translesion DNA synthesis of UV-induced DNA lesions.These results suggest that Pirh2 monoubiquitinates PolH at one of the four lysine residues (K682, K686, K694, and K709). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272731 |
Lys686 |
HQGKRNPkSPLACTN |
Homo sapiens |
|
| pmid |
sentence |
| 21791603 |
Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis. Specifically, we show that Pirh2, a target of the p53 tumor suppressor, monoubiquitinates PolH at one of multiple lysine residues.we show that monoubiquitination of PolH alters the ability of PolH to translocate to replication foci for translesion DNA synthesis of UV-induced DNA lesions.These results suggest that Pirh2 monoubiquitinates PolH at one of the four lysine residues (K682, K686, K694, and K709). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272732 |
Lys694 |
SPLACTNkRPRPEGM |
Homo sapiens |
|
| pmid |
sentence |
| 21791603 |
Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis. Specifically, we show that Pirh2, a target of the p53 tumor suppressor, monoubiquitinates PolH at one of multiple lysine residues.we show that monoubiquitination of PolH alters the ability of PolH to translocate to replication foci for translesion DNA synthesis of UV-induced DNA lesions.These results suggest that Pirh2 monoubiquitinates PolH at one of the four lysine residues (K682, K686, K694, and K709). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272733 |
Lys709 |
QTLESFFkPLTH |
Homo sapiens |
|
| pmid |
sentence |
| 21791603 |
Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis. Specifically, we show that Pirh2, a target of the p53 tumor suppressor, monoubiquitinates PolH at one of multiple lysine residues.we show that monoubiquitination of PolH alters the ability of PolH to translocate to replication foci for translesion DNA synthesis of UV-induced DNA lesions.These results suggest that Pirh2 monoubiquitinates PolH at one of the four lysine residues (K682, K686, K694, and K709). |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
CAMK2A | down-regulates
phosphorylation
|
RCHY1 |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156064 |
Ser155 |
CLEDIHTsRVVAHVL |
Homo sapiens |
|
| pmid |
sentence |
| 17568776 |
Phosphorylation of pirh2 by calmodulin-dependent kinase ii impairs its ability to ubiquitinate p53 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156068 |
Thr154 |
ICLEDIHtSRVVAHV |
Homo sapiens |
|
| pmid |
sentence |
| 17568776 |
Phosphorylation of pirh2 by calmodulin-dependent kinase ii impairs its ability to ubiquitinate p53 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CDK9 | down-regulates
phosphorylation
|
RCHY1 |
0.473 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201923 |
Ser211 |
VAQTPMPsEYQNMTV |
Homo sapiens |
|
| pmid |
sentence |
| 23603988 |
We showed that cdk9 phosphorylates pirh2 on ser-211 and thr-217 residues through their physical interaction. Phosphorylation of pirh2 renders it inactive and may contribute to p53-inhibition of transcriptional elongation of the hiv-1 ltr. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201927 |
Thr217 |
PSEYQNMtVDILCND |
Homo sapiens |
|
| pmid |
sentence |
| 23603988 |
We showed that cdk9 phosphorylates pirh2 on ser-211 and thr-217 residues through their physical interaction. Phosphorylation of pirh2 renders it inactive and may contribute to p53-inhibition of transcriptional elongation of the hiv-1 ltr. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
Ub:E2 | up-regulates activity 
ubiquitination
|
RCHY1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271021 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RCHY1 | down-regulates quantity by destabilization
polyubiquitination
|
COPE |
0.484 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272630 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17721809 |
PIRH2 promotes the ubiquitylation of epsilon-COP in vitro and in vivo and consequently promotes the degradation of epsilon-COP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RCHY1
- 
- 