3.0
Summary
| Name |  TRPM7View Modifications |
| Full Name | Transient receptor potential cation channel subfamily M member 7 |
| Synonyms | Channel-kinase 1, Long transient receptor potential channel 7, LTrpC-7, LTrpC7 | CHAK1, LTRPC7 |
| Primary ID | Q96QT4 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | TRPM7 | up-regulates activity 
phosphorylation
|
PLCG2 | |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | TRPM7 | up-regulates
phosphorylation
|
ANXA1 | 0.559 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRPM7 | up-regulates activity
phosphorylation
|
EEF2K | 0.32 |
| Publications: | 1 | Organism: | Homo Sapiens | |