Summary

Name PLCG2
Full Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Synonyms Phosphoinositide phospholipase C-gamma-2, Phospholipase C-IV, PLC-IV, Phospholipase C-gamma-2, PLC-gamma-2
Primary ID P16885
Links - -
Type protein
Relations 16
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation PLCG2 0.55
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PLCG2 0.14
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PLCG2 0.14
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PLCG2 0.55
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PLCG2 0.31
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PLCG2 0.31
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Macrophage_differentiation 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates img/direct-activation.png PLCG2 0.34
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle