Summary

Name PLCG2
Full Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Synonyms Phosphoinositide phospholipase C-gamma-2, Phospholipase C-IV, PLC-IV, Phospholipase C-gamma-2, PLC-gamma-2
Primary ID P16885
Links - -
Type protein
Relations 25
Pathways B-cell activation, Monocyte: Macrophage differentiation
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation PLCG2 0.265
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CDKN1A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PLCG2 0.778
Publications: 4 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates activity img/direct-activation.png phosphorylation PLCG2 0.617
Publications: 2 Organism: In Vitro
Pathways:B-cell activation
+ up-regulates activity img/direct-activation.png phosphorylation PLCG2 0.548
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PLCG2 0.778
Publications: 2 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates img/direct-activation.png phosphorylation PLCG2 0.554
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PLCG2 0.571
Publications: 2 Organism: In Vitro
Pathways:B-cell activation
+ up-regulates img/direct-activation.png PLCG2 0.37
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Proliferation 0.7
Publications: 1 Organism: Rattus Norvegicus
Pathways:B-cell activation
+ down-regulates activity img/direct_inhibition.png dephosphorylation PLCG2 0.313
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates img/indirect-activation.png Macrophage_differentiation 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png chemical modification 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates quantity img/direct-activation.png chemical modification 1,2-diacyl-sn-glycerol 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates quantity img/direct-activation.png chemical modification 1D-myo-inositol 1,4,5-trisphosphate 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation
+ up-regulates img/indirect-activation.png Apoptosis 0.7
Publications: 1 Organism: Rattus Norvegicus