Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273806 |
Tyr199 |
KYPIVEQyLKTKKNS |
Homo sapiens |
Coronary Artery Smooth Muscle Cell |
pmid |
sentence |
30814251 |
We report herein that the YLK motif is contained within an SRC homology 2 domain and is directly phosphorylated by SRC proto-oncogene, nonreceptor tyrosine kinase (SRC) at Tyr198. Using a PANX1 Tyr198-specific antibody, SFK inhibitors, SRC knockdown, temperature-dependent SRC cells, and kinase assays, we found that PANX1-mediated ATP release and vasoconstriction involves constitutive phosphorylation of PANX1 Tyr198 by SRC. |
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