3.0
Summary
| Name |  MED15
|
| Full Name | Mediator of RNA polymerase II transcription subunit 15 |
| Synonyms | Activator-recruited cofactor 105 kDa component, ARC105, CTG repeat protein 7a, Mediator complex subunit 15, Positive cofactor 2 glutamine/Q-rich-associated protein, PC2 glutamine/Q-rich-associated protein, TPA-inducible gene 1 protein, TIG-1, Trinucleotide repeat-containing gene 7 protein | ARC105, CTG7A, PCQAP, TIG1, TNRC7 |
| Primary ID | Q96RN5 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MED15 | form complex 
binding
|
Core mediator complex | 0.793 |
| Publications: | 1 | Organism: | Homo Sapiens | |