Relation Results

Summary

Name CSF3R
Full Name Granulocyte colony-stimulating factor receptor
Synonyms G-CSF receptor, G-CSF-R | GCSFR
Primary ID Q99062
Links - -
Type protein
Relations 6
Function Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differien ...
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Type: Score: Layout: SPV 
0.3870.3220.5910.766HCKCSF3RCSF1CSF2CSF3

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ HCKup-regulates activity img/direct-activation.png phosphorylation CSF3R 0.387
Identifier Residue Sequence Organism Cell Line
SIGNOR-251263 Tyr752 GTSDQVLyGQLLGSP in vitro
pmid sentence
Hck becomes activated upon G-CSF treatment and is, in turn, able to phosphorylate the G-CSF-R, indicating a clear functional and physical involvement in G-CSF signaling. the ability of Hck to phosphorylate the G-CSF-R in vitro, both Y728 and Y763 fit the Src consensus phosphorylation site
Identifier Residue Sequence Organism Cell Line
SIGNOR-251264 Tyr787 LTPSPKSyENLWFQA in vitro
pmid sentence
Hck becomes activated upon G-CSF treatment and is, in turn, able to phosphorylate the G-CSF-R, indicating a clear functional and physical involvement in G-CSF signaling. the ability of Hck to phosphorylate the G-CSF-R in vitro, both Y728 and Y763 fit the Src consensus phosphorylation site. we investigated the activation of Hck by the G-CSF-R in intact cells as well as in vitro. These studies revealed recruitment of Hck to activated G-CSF-R, mediated by direct binding via its SH2 domain to multiple phosphotyrosines of the receptor. In addition, we show that Hck becomes activated upon G-CSF treatment and is, in turn, able to phosphorylate the G-CSF-R, indicating a clear functional and physical involvement in G-CSF signaling.
Publications: 2 Organism: In Vitro
+ CSF1up-regulates img/direct-activation.png binding CSF3R 0.322
Identifier Residue Sequence Organism Cell Line
SIGNOR-144737 Homo sapiens
pmid sentence
A crystal structure of the signaling complex between human granulocyte colony-stimulating factor (gcsf) and a ligand binding region of gcsf receptor (gcsf-r), has been determined to 2.8 a resolution
Publications: 1 Organism: Homo Sapiens
+ CSF2up-regulates img/direct-activation.png binding CSF3R 0.591
Identifier Residue Sequence Organism Cell Line
SIGNOR-144740 Homo sapiens Neutrophil
pmid sentence
A g-csfr expression plasmid was introduced into interleukin-3 (il-3)-dependent mouse myeloid precursor fdc-p1 cells that normally do not respond to g-csf. G-csf stimulated proliferation of the transformants. These results suggested that the g-csfr, but not the il-3/gm-csf receptors, transduced the neutrophilic differentiation signal into cells
Identifier Residue Sequence Organism Cell Line
SIGNOR-31963 Homo sapiens Neutrophil
pmid sentence
A g-csfr expression plasmid was introduced into interleukin-3 (il-3)-dependent mouse myeloid precursor fdc-p1 cells that normally do not respond to g-csf. G-csf stimulated proliferation of the transformants these results suggested that the g-csfr, but not the il-3/gm-csf receptors, transduced the neutrophilic differentiation signal into cells.
Publications: 2 Organism: Homo Sapiens
+ CSF3up-regulates img/direct-activation.png binding CSF3R 0.766
Identifier Residue Sequence Organism Cell Line
SIGNOR-144743 Homo sapiens
pmid sentence
The gcsf:gcsf-r complex formed a 2:2 stoichiometry by means of a cross-over interaction between the ig-like domains of gcsf-r and gcsf. the ig-like domain cross-over structure necessary for gcsf-r activation is consistent with previously reported thermodynamic and mutational analyses.
Publications: 1 Organism: Homo Sapiens
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