Relation Results

Summary

Name CSF2
Full Name Granulocyte-macrophage colony-stimulating factor
Synonyms GM-CSF, Colony-stimulating factor, CSF, Molgramostin, Sargramostim | GMCSF
Primary ID P04141
Links - -
Type protein
Relations 7
Pathways Monocyte: Macrophage differentiation, Chemokines PDAC
Function Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, e ...
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Type: Score: Layout: SPV 
0.8560.590.20.86CSF2CSF2RACSF3RHBG2CSF2RA/CSF2RB

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Relations
Regulator
Mechanism
target
score ℹ
+ CSF2up-regulates activity img/direct-activation.png binding CSF2RA 0.856
Identifier Residue Sequence Organism Cell Line
SIGNOR-249501 Homo sapiens Macrophage
pmid sentence
The GM-CSF receptor (CSF2R) is a heterodimer composed of a specific ligand-binding subunit (CSF2Ralpha) and a common signal-transduction subunit (CSF2Rbeta)
Publications: 1 Organism: Homo Sapiens
+ CSF2up-regulates img/direct-activation.png binding CSF3R 0.59
Identifier Residue Sequence Organism Cell Line
SIGNOR-31963 Homo sapiens Neutrophil
pmid sentence
A g-csfr expression plasmid was introduced into interleukin-3 (il-3)-dependent mouse myeloid precursor fdc-p1 cells that normally do not respond to g-csf. G-csf stimulated proliferation of the transformants these results suggested that the g-csfr, but not the il-3/gm-csf receptors, transduced the neutrophilic differentiation signal into cells.
Identifier Residue Sequence Organism Cell Line
SIGNOR-144740 Homo sapiens Neutrophil
pmid sentence
A g-csfr expression plasmid was introduced into interleukin-3 (il-3)-dependent mouse myeloid precursor fdc-p1 cells that normally do not respond to g-csf. G-csf stimulated proliferation of the transformants. These results suggested that the g-csfr, but not the il-3/gm-csf receptors, transduced the neutrophilic differentiation signal into cells
Publications: 2 Organism: Homo Sapiens
+ CSF2up-regulates img/direct-activation.png binding CSF2RA 0.856
Identifier Residue Sequence Organism Cell Line
SIGNOR-49126 Homo sapiens
pmid sentence
We have determined the nmr structure of a ligand-binding domain of the granulocyte colony-stimulating factor (g-csf) receptor comparisons between the spectra of the 15n-labelled domain with and without g-csf indicate that the major ligand-recognition site is on the fg loop just upstream of the wsxws sequence.
Identifier Residue Sequence Organism Cell Line
SIGNOR-72458 Homo sapiens
pmid sentence
We have determined the nmr structure of a ligand-binding domain of the granulocyte colony-stimulating factor (g-csf) receptor comparisons between the spectra of the 15n-labelled domain with and without g-csf indicate that the major ligand-recognition site is on the fg loop just upstream of the wsxws sequence.
Publications: 2 Organism: Homo Sapiens
+ CSF2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HBG2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-251776 Homo sapiens Erythroblast
pmid sentence
Granulocyte-macrophage colony-stimulating factor reactivates fetal hemoglobin synthesis in erythroblast clones from normal adults.
Publications: 1 Organism: Homo Sapiens
+ CSF2up-regulates img/direct-activation.png binding CSF2RA/CSF2RB 0.86
Identifier Residue Sequence Organism Cell Line
SIGNOR-255581 Homo sapiens Monocyte
pmid sentence
GM-CSF elicits these diverse responses through the GM-CSF receptor (GMR).
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
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