Summary

Name HBEGF
Full Name Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor
Synonyms HBEGF_HUMAN | DTR, DTS, HEGFL
Primary ID Q99075
Links - -
Type protein
Relations 6
Function Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

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Relations

Regulator Mechanism target score ℹ
+ MMP1up-regulates activity img/direct-activation.png cleavage HBEGF 0.33
Publications: 1 Organism: Homo Sapiens
+ HBEGFup-regulates img/direct-activation.png binding ERBB4 0.75
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ MMP3up-regulates img/direct-activation.png cleavage HBEGF 0.518
Publications: 1 Organism: Homo Sapiens
+ ADAM17up-regulates activity img/direct-activation.png cleavage HBEGF 0.591
Publications: 1 Organism: Homo Sapiens
+ HBEGFup-regulates img/direct-activation.png binding EGFR 0.768
Publications: 1 Organism: Homo Sapiens