Relation Results

Summary

Name TBCB
Full Name Tubulin-folding cofactor B
Synonyms Cytoskeleton-associated protein 1, Cytoskeleton-associated protein CKAPI, Tubulin-specific chaperone B | CG22, CKAP1
Primary ID Q99426
Links - -
Type protein
Relations 3
Function Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin t ...
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Type: Score: Layout: SPV 
0.4510.246PAK1TBCBCUL3

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PAK1up-regulates img/direct-activation.png phosphorylation TBCB 0.451
Identifier Residue Sequence Organism Cell Line
SIGNOR-135460 Ser128 VRSFLKRsKLGRYNE Homo sapiens Breast Cancer Cell
pmid sentence
P21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor b. Pak1 directly phosphorylated tcob in vitro and in vivo on serines 65 and 128 and colocalized with tcob on newly polymerized microtubules and on centrosomes. Pak1 phosphorylation is necessary for normal tcob function
Identifier Residue Sequence Organism Cell Line
SIGNOR-135464 Ser65 GVDDKFYsKLDQEDA Homo sapiens Breast Cancer Cell
pmid sentence
P21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor b. Pak1 directly phosphorylated tcob in vitro and in vivo on serines 65 and 128 and colocalized with tcob on newly polymerized microtubules and on centrosomes. Pak1 phosphorylation is necessary for normal tcob function
Publications: 2 Organism: Homo Sapiens
+ CUL3down-regulates quantity img/direct_inhibition.png ubiquitination TBCB 0.246
Identifier Residue Sequence Organism Cell Line
SIGNOR-268945 Mus musculus Brain
pmid sentence
Gigaxonin is the substrate-specific adaptor for a new Cul3-E3-ubiquitin ligase family that promotes the proteasome dependent degradation of its partners MAP1B, MAP8 and tubulin cofactor B.
Publications: 1 Organism: Mus Musculus
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