+ |
PAK1 | up-regulates
phosphorylation
|
TBCB |
0.46 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-135460 |
Ser128 |
VRSFLKRsKLGRYNE |
Homo sapiens |
Breast Cancer Cell |
pmid |
sentence |
15831477 |
P21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor b. Pak1 directly phosphorylated tcob in vitro and in vivo on serines 65 and 128 and colocalized with tcob on newly polymerized microtubules and on centrosomes. Pak1 phosphorylation is necessary for normal tcob function |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-135464 |
Ser65 |
GVDDKFYsKLDQEDA |
Homo sapiens |
Breast Cancer Cell |
pmid |
sentence |
15831477 |
P21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor b. Pak1 directly phosphorylated tcob in vitro and in vivo on serines 65 and 128 and colocalized with tcob on newly polymerized microtubules and on centrosomes. Pak1 phosphorylation is necessary for normal tcob function |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
CUL3 | down-regulates quantity
ubiquitination
|
TBCB |
0.247 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-268945 |
|
|
Mus musculus |
Brain |
pmid |
sentence |
18680552 |
Gigaxonin is the substrate-specific adaptor for a new Cul3-E3-ubiquitin ligase family that promotes the proteasome dependent degradation of its partners MAP1B, MAP8 and tubulin cofactor B. |
|
Publications: |
1 |
Organism: |
Mus Musculus |