+ |
CDC5L | up-regulates activity
binding
|
HNRNPM |
0.618 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-239410 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
20467437 |
hnRNP-M interacts directly with CDC5L and PLRG1 in vivo. we investigated whether the function of hnRNP-M in alternative splicing was affected by the central region mapped as essential for binding to the CDC5L/PLRG1 proteins. We conclude that loss of the CDC5L/PLRG1 interaction domain in hnRNP-M correlates with a loss of ability to modulate alternative splice site selection in this assay. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TTF2 | up-regulates quantity by stabilization
binding
|
CDC5L |
0.443 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-224460 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
12927788 |
HLodestar/HuF2 associates with CDC5L in cell lysates and HeLa nuclear extracts. It is possible that during the cell division cycle, hLodestar/HuF2s associates with transcription/splicing complexes in order to inhibit transcription/splicing prior to the start of mitosis and/or functions in stabilizing nuclear complexes containing splicing factors (e.g., the CDC5L complex) so that these are available for re-initiation of splicing at the end of mitosis when gene expression is re-established in cells. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CDC5L | form complex
binding
|
PRP19-CDC5L |
0.907 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271974 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
20176811 |
In this study, we affinity purified the human Prp19/CDC5L complex from HeLa cell lines stably expressing FLAG-AD002 or FLAG-SPF27 and determined its molecular architecture and EM structure. To learn more about the spatial organization of the human Prp19 (hPrp19)/CDC5L complex, which is comprised of hPrp19, CDC5L, PRL1, AD002, SPF27, CTNNBL1, and HSP73, we purified native hPrp19/CDC5L complexes from HeLa cells stably expressing FLAG-tagged AD002 or SPF27. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |