Summary

Name RNF2
Full Name E3 ubiquitin-protein ligase RING2
Synonyms Huntingtin-interacting protein 2-interacting protein 3, HIP2-interacting protein 3, Protein DinG, RING finger protein 1B, RING1b, RING finger protein 2, RING finger protein BAP-1, RING-type E3 ubiquitin transferase RING2 | BAP1, DING, HIPI3, RING1B
Primary ID Q99496
Links - -
Type protein
Relations 6
Function E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:25519132, PubMed:21772249, PubMed:25355358, PubMed:26151332). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation (By similarity). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:26151332). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:21772249). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ KDM2Bup-regulates activity img/direct-activation.png binding RNF2 0.628
Publications: 1 Organism: Homo Sapiens
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination RNF2 0.2
Publications: 1 Organism: Homo Sapiens
+ RNF2form complex img/form-complex.png binding Polycomb repressive complex 1 0.821
Publications: 1 Organism: Homo Sapiens
+ RNF2form complex img/form-complex.png binding Noncanonical PRC1 0.573
Publications: 1 Organism: Mus Musculus
+ UBAP2Lup-regulates activity img/direct-activation.png binding RNF2 0.357
Publications: 1 Organism: Homo Sapiens
+ BCORup-regulates activity img/direct-activation.png binding RNF2 0.561
Publications: 1 Organism: Homo Sapiens