| + |
KDM2B | up-regulates activity 
binding
|
Noncanonical PRC1 |
0.675 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252247 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 25533466 |
We show that FBXL10/KDM2B is an anti-adipogenic factor that is up-regulated during the early phase of 3T3-L1 preadipocyte differentiation and in adipose tissue in a diet-induced model of obesity. Interestingly, inhibition of adipogenesis does not require the JmjC demethylase domain of FBXL10, but it does require the F-box and leucine-rich repeat domains, which we show recruit a noncanonical polycomb repressive complex 1 (PRC1) containing RING1B, SKP1, PCGF1, and BCOR. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RNF2 | form complex 
binding
|
Noncanonical PRC1 |
0.573 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255277 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25533466 |
inhibition of adipogenesis does not require the JmjC demethylase domain of FBXL10, but it does require the F-box and leucine-rich repeat domains, which we show recruit a noncanonical polycomb repressive complex 1 (PRC1) containing RING1B, SKP1, PCGF1, and BCOR. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
BCOR | form complex
binding
|
Noncanonical PRC1 |
0.562 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255276 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25533466 |
inhibition of adipogenesis does not require the JmjC demethylase domain of FBXL10, but it does require the F-box and leucine-rich repeat domains, which we show recruit a noncanonical polycomb repressive complex 1 (PRC1) containing RING1B, SKP1, PCGF1, and BCOR. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Noncanonical PRC1 | down-regulates quantity by repression 
transcriptional regulation
|
PPARG |
0.326 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252251 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 25533466 |
We concluded that FBXL10 recruits the noncanonical PRC1 complex to directly repress Cdk1, Uhrf1, and Pparg that may account for the FBXL10-mediated inhibition of adipogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PCGF1 | form complex
binding
|
Noncanonical PRC1 |
0.712 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255279 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25533466 |
inhibition of adipogenesis does not require the JmjC demethylase domain of FBXL10, but it does require the F-box and leucine-rich repeat domains, which we show recruit a noncanonical polycomb repressive complex 1 (PRC1) containing RING1B, SKP1, PCGF1, and BCOR. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SKP1 | form complex
binding
|
Noncanonical PRC1 |
0.452 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255278 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25533466 |
inhibition of adipogenesis does not require the JmjC demethylase domain of FBXL10, but it does require the F-box and leucine-rich repeat domains, which we show recruit a noncanonical polycomb repressive complex 1 (PRC1) containing RING1B, SKP1, PCGF1, and BCOR. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Noncanonical PRC1 | down-regulates quantity by repression
transcriptional regulation
|
CDK1 |
0.526 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252249 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 25533466 |
We concluded that FBXL10 recruits the noncanonical PRC1 complex to directly repress Cdk1, Uhrf1, and Pparg that may account for the FBXL10-mediated inhibition of adipogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Noncanonical PRC1 | down-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252248 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 25533466 |
We show that FBXL10/KDM2B is an anti-adipogenic factor that is up-regulated during the early phase of 3T3-L1 preadipocyte differentiation and in adipose tissue in a diet-induced model of obesity. Interestingly, inhibition of adipogenesis does not require the JmjC demethylase domain of FBXL10, but it does require the F-box and leucine-rich repeat domains, which we show recruit a noncanonical polycomb repressive complex 1 (PRC1) containing RING1B, SKP1, PCGF1, and BCOR. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Noncanonical PRC1 | down-regulates quantity by repression
transcriptional regulation
|
UHRF1 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252250 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 25533466 |
We concluded that FBXL10 recruits the noncanonical PRC1 complex to directly repress Cdk1, Uhrf1, and Pparg that may account for the FBXL10-mediated inhibition of adipogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
Noncanonical PRC1