+ |
CHKA | down-regulates quantity by destabilization
phosphorylation
|
PLIN2 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267649 |
Tyr232 |
TKLHSRAyQQALSRV |
Homo sapiens |
Glioblastoma Cell |
pmid |
sentence |
34929314 |
In addition, as a protein kinase, CHKalpha2 phosphorylates PLIN2 at Tyrosine 232 and PLIN3 at Tyrosine 251. Phosphorylated PLIN2 and PLIN3 are separated from lipid droplets and degraded by Hsc70-mediated autophagy, thereby promoting lipid droplet lipolysis, fatty acid oxidation and glioblastoma growth |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PPARA | up-regulates quantity by expression
transcriptional regulation
|
PLIN2 |
0.529 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255046 |
|
|
Homo sapiens |
Caki-1 Cell |
pmid |
sentence |
17150915 |
To investigate the intimate function of PPARalpha in the kidney, we analyzed the target gene expression in human metastatic renal cell carcinoma cell line, Caki-1, using small interfering RNA (siRNA) against PPARalpha and real-time RT-PCR methods. We found that some selected genes (long-chain fatty-acid-CoA ligase (FACL1), carnitine palmitoyltransferase 1A (CPT1A), adipose differentiation-related protein (ADRP) and aquaporin 3 (AQP3)) were down-regulated by PPARalpha siRNA. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |