| + |
PIK3R4 | up-regulates 
binding
|
PIK3C3 |
0.938 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45664 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8999962 |
Recombinant p150 associated with ptdins 3-kinase in vitro in a stable manner, resulting in a 2-fold increase in lipid kinase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIK3R4 | form complex 
binding
|
Vps34 Complex I |
0.917 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260317 |
|
|
in vitro |
|
| pmid |
sentence |
| 30397185 |
PtdIns3P recruits specific recognition modules that are common in protein-sorting pathways, such as autophagy and endocytic sorting. It is best characterized in two heterotetramers, complexes I and II. Complex I is composed of VPS34, VPS15, Beclin 1, and autophagy-related gene (ATG)14L, whereas complex II replaces ATG14L with UVRAG. |Complexes I and II are critical for early events in autophagy and endocytic sorting, respectively. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RAB5A | up-regulates activity
binding
|
PIK3R4 |
0.434 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260708 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 27411398 |
Vps34 PI 3-kinase activity18 is stimulated by complex formation with the protein kinase Vps15|Rab5GTP binds Vps15, enhancing Vps34 activity |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PIK3R4 | up-regulates activity
binding
|
PIK3C3 |
0.938 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260709 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 27411398 |
Vps34 PI 3-kinase activity18 is stimulated by complex formation with the protein kinase Vps15|Rab5GTP binds Vps15, enhancing Vps34 activity |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PIK3R4 | form complex
binding
|
Vps34 Complex II |
0.881 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260321 |
|
|
in vitro |
|
| pmid |
sentence |
| 30397185 |
PtdIns3P recruits specific recognition modules that are common in protein-sorting pathways, such as autophagy and endocytic sorting. It is best characterized in two heterotetramers, complexes I and II. Complex I is composed of VPS34, VPS15, Beclin 1, and autophagy-related gene (ATG)14L, whereas complex II replaces ATG14L with UVRAG. |Complexes I and II are critical for early events in autophagy and endocytic sorting, respectively. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
NRBF2 | down-regulates activity 
binding
|
PIK3R4 |
0.655 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265878 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 28059666 |
NRBF2 S113 and S120 phosphorylation negatively regulates autophagy. Phosphorylated NRBF2 inhibits autophagy, preferentially binds a nonautophagic form of the PtdIns3K complex consisting of PIK3C3-PIK3R4 only, and this NRBF2-associated PtdIns3K complex has low lipid kinase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PIK3R4
- 
- 