| + |
MTOR | up-regulates activity 
phosphorylation
|
NRBF2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265874 |
Ser113 |
AEDAEGQsPLSQKYS |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 28059666 |
Human NRBF2 is phosphorylated by MTORC1 at S113 and S120. Upon nutrient starvation or MTORC1 inhibition, NRBF2 phosphorylation is diminished. Phosphorylated NRBF2 preferentially interacts with PIK3C3/PIK3R4. Suppression of NRBF2 phosphorylation by MTORC1 inhibition alters its binding preference from PIK3C3/PIK3R4 to ATG14/BECN1, leading to increased autophagic PtdIns3K complex assembly, as well as enhancement of ULK1 protein complex association. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265875 |
Ser120 |
SPLSQKYsPSTEKCL |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 28059666 |
Human NRBF2 is phosphorylated by MTORC1 at S113 and S120. Upon nutrient starvation or MTORC1 inhibition, NRBF2 phosphorylation is diminished. Phosphorylated NRBF2 preferentially interacts with PIK3C3/PIK3R4. Suppression of NRBF2 phosphorylation by MTORC1 inhibition alters its binding preference from PIK3C3/PIK3R4 to ATG14/BECN1, leading to increased autophagic PtdIns3K complex assembly, as well as enhancement of ULK1 protein complex association. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
mTORC1 | up-regulates activity
phosphorylation
|
NRBF2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265876 |
Ser113 |
AEDAEGQsPLSQKYS |
Homo sapiens |
|
| pmid |
sentence |
| 28059666 |
Human NRBF2 is phosphorylated by MTORC1 at S113 and S120. Upon nutrient starvation or MTORC1 inhibition, NRBF2 phosphorylation is diminished. Phosphorylated NRBF2 preferentially interacts with PIK3C3/PIK3R4. Suppression of NRBF2 phosphorylation by MTORC1 inhibition alters its binding preference from PIK3C3/PIK3R4 to ATG14/BECN1, leading to increased autophagic PtdIns3K complex assembly, as well as enhancement of ULK1 protein complex association. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265877 |
Ser120 |
SPLSQKYsPSTEKCL |
Homo sapiens |
|
| pmid |
sentence |
| 28059666 |
Human NRBF2 is phosphorylated by MTORC1 at S113 and S120. Upon nutrient starvation or MTORC1 inhibition, NRBF2 phosphorylation is diminished. Phosphorylated NRBF2 preferentially interacts with PIK3C3/PIK3R4. Suppression of NRBF2 phosphorylation by MTORC1 inhibition alters its binding preference from PIK3C3/PIK3R4 to ATG14/BECN1, leading to increased autophagic PtdIns3K complex assembly, as well as enhancement of ULK1 protein complex association. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
NRBF2 | down-regulates activity 
binding
|
PIK3R4 |
0.655 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265878 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 28059666 |
NRBF2 S113 and S120 phosphorylation negatively regulates autophagy. Phosphorylated NRBF2 inhibits autophagy, preferentially binds a nonautophagic form of the PtdIns3K complex consisting of PIK3C3-PIK3R4 only, and this NRBF2-associated PtdIns3K complex has low lipid kinase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NRBF2 | down-regulates activity
binding
|
PIK3C3 |
0.678 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265879 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 28059666 |
NRBF2 S113 and S120 phosphorylation negatively regulates autophagy. Phosphorylated NRBF2 inhibits autophagy, preferentially binds a nonautophagic form of the PtdIns3K complex consisting of PIK3C3-PIK3R4 only, and this NRBF2-associated PtdIns3K complex has low lipid kinase activity. Phosphorylated NRBF2 inhibits autophagy, preferentially binds a nonautophagic form of the PtdIns3K complex consisting of PIK3C3-PIK3R4 only, and this NRBF2-associated PtdIns3K complex has low lipid kinase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NRBF2 | down-regulates activity
binding
|
Vps34 Complex I |
0.708 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265880 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 24785657 |
We have now identified NRBF2 (nuclear receptor-binding factor 2) as a new member of Vps34 Complex I. NRBF2 binds to complexes that include Vps34, Vps15, Beclin-1 and ATG-14L, but not the Vps34 Complex II component UVRAG (UV radiation resistance-associated gene). NRBF2 directly interacts with Vps15 via the Vps15 WD40 domain as well as other regions of Vps15. Thus NRBF2 plays a critical role in the induction of starvation-induced autophagy as a specific member of Vps34 Complex I. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NRBF2
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