| + |
CDK1 | down-regulates 
phosphorylation
|
PIK3C3 |
0.42 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165768 |
Thr159 |
DGSEPTKtPGRTSST |
Homo sapiens |
|
| pmid |
sentence |
| 20513426 |
We show that vps34 is phosphorylated on thr159 by cdk1, thr159 phosphorylation negatively regulates the ptdins3 kinase activity of vps34 and autophagy |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK5 | down-regulates
phosphorylation
|
PIK3C3 |
0.358 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165772 |
Thr159 |
DGSEPTKtPGRTSST |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20513426 |
Thr159 phosphorylation negatively regulates the ptdins3 kinase activity of vps34 and autophagy cdk5/p25, a neuronal cdk shown to play a role in alzheimer's disease, can also phosphorylate thr159 of vps34. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK5 | down-regulates activity
phosphorylation
|
PIK3C3 |
0.358 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259811 |
Thr668 |
ENLDLKLtPYKVLAT |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20513426 |
Phosphorylation of Vps34 on Thr159 inhibits its interaction with Beclin 1. two additional amino acids in Vps34, Thr159 and Thr668, were found to be phosphorylated only after co-transfection with Cdk5/p25 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKD1 | up-regulates activity 
phosphorylation
|
PIK3C3 |
0.372 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278495 |
Thr677 |
YKVLATStKHGFMQF |
Homo sapiens |
|
| pmid |
sentence |
| 22095288 |
PKD phosphorylates Vps34, leading to activation of Vps34, phosphatydilinositol-3-phosphate formation, and autophagosome formation.|Therefore, PKD phosphorylates Vps34 on multiple sites, including Thr677 within the catalytic domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIK3C3 | up-regulates 
|
AKT1 |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252633 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10698680 |
Pkb is activated through recruitment to cellular membranes by pi3k lipid products and phosphorylation by 3h-phosphoinositide-dependent kinase-1 (pdk1) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
wortmannin | down-regulates
chemical inhibition
|
PIK3C3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260730 |
|
|
Chlorocebus aethiops |
Vero Cell |
| pmid |
sentence |
| 22253445 |
From these results, we conclude that LY294002 and wortmannin inhibit SARS pseudovirus entry by targeting PI4KB and that PI4KB is involved in SARS-CoV S-mediated entry into VeroE6 cells. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
ATG14 | up-regulates activity
binding
|
PIK3C3 |
0.882 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235448 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 19270693 |
Characterization of the new proteins revealed that atg14l enhances vps34 lipid kinase activity and upregulates autophagy, |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Autophagy |
| + |
RUBCN | down-regulates
binding
|
PIK3C3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184547 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19270693 |
The run or cysteine-rich domain of rubicon appears to be inhibitory to the binding of rubicon to beclin 1 and vps34 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIK3C3 | up-regulates activity
binding
|
BECN1 |
0.936 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184521 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19270693 |
The beclin 1-vps34 interaction regulates autophagy. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Autophagy |
| + |
3-methyladenine | down-regulates
chemical inhibition
|
PIK3C3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205636 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIK3C3 | up-regulates
chemical modification
|
1-phosphatidyl-1D-myo-inositol 3-phosphate |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45606 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8999962 |
Vps34p phosphorylates phosphatidylinositol (ptdins) at the 3?-Position of the inositol ring, but not ptdins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIK3C3 | up-regulates
binding
|
PTEN |
0.667 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164075 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20212113 |
Direct positive regulation of pten by the p85 subunit of phosphatidylinositol 3-kinase.Thus p85 regulates both p110-pi3k and pten-phosphatase enzymes through direct interaction |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LY294002 | down-regulates
chemical inhibition
|
PIK3C3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260731 |
|
|
Chlorocebus aethiops |
Vero Cell |
| pmid |
sentence |
| 22253445 |
From these results, we conclude that LY294002 and wortmannin inhibit SARS pseudovirus entry by targeting PI4KB and that PI4KB is involved in SARS-CoV S-mediated entry into VeroE6 cells. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
NRBF2 | down-regulates activity
binding
|
PIK3C3 |
0.688 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265879 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 28059666 |
NRBF2 S113 and S120 phosphorylation negatively regulates autophagy. Phosphorylated NRBF2 inhibits autophagy, preferentially binds a nonautophagic form of the PtdIns3K complex consisting of PIK3C3-PIK3R4 only, and this NRBF2-associated PtdIns3K complex has low lipid kinase activity. Phosphorylated NRBF2 inhibits autophagy, preferentially binds a nonautophagic form of the PtdIns3K complex consisting of PIK3C3-PIK3R4 only, and this NRBF2-associated PtdIns3K complex has low lipid kinase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIK3R4 | up-regulates
binding
|
PIK3C3 |
0.94 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45664 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8999962 |
Recombinant p150 associated with ptdins 3-kinase in vitro in a stable manner, resulting in a 2-fold increase in lipid kinase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC | up-regulates activity
phosphorylation
|
PIK3C3 |
0.421 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278456 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24582588 |
Given that VPS34 is activated by Src mediated tyrosine phosphorylation, we next determined if VPS34 was tyrosine phosphorylated following insulin treatment.|These data indicate that VPS34 is an effector of insulin-mediated signal transduction and that Src phosphorylation of VPS34 is required for this function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIK3C3 | form complex 
binding
|
Vps34 Complex I |
0.919 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260316 |
|
|
in vitro |
|
| pmid |
sentence |
| 30397185 |
PtdIns3P recruits specific recognition modules that are common in protein-sorting pathways, such as autophagy and endocytic sorting. It is best characterized in two heterotetramers, complexes I and II. Complex I is composed of VPS34, VPS15, Beclin 1, and autophagy-related gene (ATG)14L, whereas complex II replaces ATG14L with UVRAG. |Complexes I and II are critical for early events in autophagy and endocytic sorting, respectively. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Autophagy |
| + |
PIK3C3 | up-regulates
relocalization
|
AKT |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75370 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10698680 |
One of the best characterized targets of pi3k lipid products is the protein kinase akt or protein kinase b (pkb). In quiescent cells, pkb resides in the cytosol in a low-activity conformation. Upon cellular stimulation, pkb is activated through recruitment to cellular membranes by pi3k lipid products and phosphorylation by 3h-phosphoinositide-dependent kinase-1 (pdk1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIK3C3 | up-regulates
|
AKT |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75376 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10698680 |
Pkb is activated through recruitment to cellular membranes by pi3k lipid products and phosphorylation by 3h-phosphoinositide-dependent kinase-1 (pdk1) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB7A | up-regulates activity
guanine nucleotide exchange factor
|
PIK3C3 |
0.486 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261302 |
|
|
|
BHK Cell |
| pmid |
sentence |
| 14617358 |
The p150 adapter protein is in a complex with rab7. The hVPS34/p150 complex colocalized with rab7 on late endosomes and hVPS34 activity was dependent on nucleotide cycling of rab7 |
|
| Publications: |
1 |
| + |
Cullin 3-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
PIK3C3 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272418 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26687681 |
Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination. KLHL20 promotes ubiquitination of phagophore-residing VPS34 and Beclin-1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UVRAG | up-regulates activity
binding
|
PIK3C3 |
0.812 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181554 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18843052 |
Although both human atg14 and uvrag interact with beclin 1 and vps34. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Autophagy |
| + |
ULK1 | up-regulates activity
phosphorylation
|
PIK3C3 |
0.716 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279670 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29671878 |
In the nucleation step of autophagy, The ULK1 complex phosphorylates and activates the Beclin-1-VPS34 complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIK3C3 | up-regulates
relocalization
|
AKT1 |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252632 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10698680 |
One of the best characterized targets of pi3k lipid products is the protein kinase akt or protein kinase b (pkb). In quiescent cells, pkb resides in the cytosol in a low-activity conformation. Upon cellular stimulation, pkb is activated through recruitment to cellular membranes by pi3k lipid products and phosphorylation by 3h-phosphoinositide-dependent kinase-1 (pdk1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIK3C3 | form complex
binding
|
Vps34 Complex II |
0.896 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260320 |
|
|
in vitro |
|
| pmid |
sentence |
| 30397185 |
PtdIns3P recruits specific recognition modules that are common in protein-sorting pathways, such as autophagy and endocytic sorting. It is best characterized in two heterotetramers, complexes I and II. Complex I is composed of VPS34, VPS15, Beclin 1, and autophagy-related gene (ATG)14L, whereas complex II replaces ATG14L with UVRAG. |Complexes I and II are critical for early events in autophagy and endocytic sorting, respectively. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Autophagy |
| + |
KLHL20 | down-regulates quantity by destabilization
binding
|
PIK3C3 |
0.295 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272414 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26687681 |
Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination. KLHL20 promotes ubiquitination of phagophore-residing VPS34 and Beclin-1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIK3R4 | up-regulates activity
binding
|
PIK3C3 |
0.94 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260709 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 27411398 |
Vps34 PI 3-kinase activity18 is stimulated by complex formation with the protein kinase Vps15|Rab5GTP binds Vps15, enhancing Vps34 activity |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
4.0
PIK3C3
- 
- 