+ |
Ub:E2 | up-regulates activity
ubiquitination
|
CGRRF1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-270960 |
|
|
Homo sapiens |
|
pmid |
sentence |
34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CGRRF1 | down-regulates quantity by destabilization
polyubiquitination
|
EGFR |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272220 |
|
|
Homo sapiens |
BT-549 Cell |
pmid |
sentence |
31801577 |
CGRRF1 ubiquitinates EGFR through K48-linked ubiquitination, which leads to proteasome degradation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |