Summary

Name MTR
Full Name Methionine synthase
Synonyms 5-methyltetrahydrofolate--homocysteine methyltransferase, Vitamin-B12 dependent methionine synthase, MS |
Primary ID Q99707
Links - -
Type protein
Relations 3
Pathways One-carbon Metabolism
Function Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol (PubMed:27771510). MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate (PubMed:27771510). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:27771510).

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Relations

Regulator Mechanism target score ℹ
+ MTRdown-regulates quantity img/direct_inhibition.png chemical modification homocysteine 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:One-carbon Metabolism
+ MTRdown-regulates quantity img/direct_inhibition.png chemical modification (6S)-5-methyltetrahydrofolate(2-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:One-carbon Metabolism
+ MTRup-regulates quantity img/direct-activation.png chemical modification methionine 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:One-carbon Metabolism