Summary

Name PRMT1
Full Name Protein arginine N-methyltransferase 1
Synonyms Histone-arginine N-methyltransferase PRMT1, Interferon receptor 1-bound protein 4 | HMT2, HRMT1L2, IR1B4
Primary ID Q99873
Links - -
Type protein
Relations 6
Function Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:10749851, PubMed:16879614, PubMed:26876602). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates RBM15, promoting ubiquitination and degradation of RBM15 (PubMed:26575292). Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ PRMT1down-regulates img/direct_inhibition.png methylation CNBP 0.368
Publications: 2 Organism: Homo Sapiens
+ CSNK1A1up-regulates activity img/direct-activation.png phosphorylation PRMT1 0.2
Publications: 1 Organism: Homo Sapiens
+ RALYup-regulates quantity img/direct-activation.png post transcriptional regulation PRMT1 0.247
Publications: 1 Organism: Homo Sapiens
+ PRMT1up-regulates img/direct-activation.png methylation TAF15 0.43
Publications: 1 Organism: Homo Sapiens
+ PRMT1down-regulates activity img/direct_inhibition.png methylation FUS 0.487
Publications: 1 Organism: Homo Sapiens