Name	RNF5 View Modifications
Full Name	E3 ubiquitin-protein ligase RNF5
Synonyms	Protein G16, RING finger protein 5, RING-type E3 ubiquitin transferase RNF5, Ram1 homolog, HsRma1 \| G16, NG2, RMA1
Primary ID	Q99942
Links	- -
Type	protein
Relations	9
Function	Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses.