| + |
AKT | up-regulates activity 
phosphorylation
|
ATG4B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275836 |
Ser34 |
WILGRKYsIFTEKDE |
Homo sapiens |
Colonic Cancer Cell |
| pmid |
sentence |
| 29165041 |
In this study, we identified a novel phosphorylation site at Ser34 of ATG4B induced by AKT in HCC cells.| In brief, our results demonstrate for the first time that the phosphorylation of ATG4B at Ser34 participates in the metabolic reprogramming of HCC cells via repressing mitochondrial function, which possibly results from the Ser34 phosphorylation-induced mitochondrial enrichment of ATG4B and the subsequent inhibition of F1Fo-ATP synthase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PFKP | up-regulates activity
phosphorylation
|
ATG4B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275832 |
Ser34 |
WILGRKYsIFTEKDE |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 33607258 |
In vitro kinase assay validated that PFKP functioning as a protein kinase phosphorylated ATG4B at S34. This phosphorylation could enhance ATG4B activity and p62 degradation. In addition, PFKP S386 phosphorylation was important to ATG4B S34 phosphorylation and autophagy in HEK293T cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT1 | up-regulates activity
phosphorylation
|
ATG4B |
0.316 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275834 |
Ser34 |
WILGRKYsIFTEKDE |
Homo sapiens |
Colonic Cancer Cell |
| pmid |
sentence |
| 29165041 |
In this study, we identified a novel phosphorylation site at Ser34 of ATG4B induced by AKT in HCC cells.| In brief, our results demonstrate for the first time that the phosphorylation of ATG4B at Ser34 participates in the metabolic reprogramming of HCC cells via repressing mitochondrial function, which possibly results from the Ser34 phosphorylation-induced mitochondrial enrichment of ATG4B and the subsequent inhibition of F1Fo-ATP synthase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK26 | up-regulates activity
phosphorylation
|
ATG4B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275833 |
Ser383 |
RLERFFDsEDEDFEI |
|
|
| pmid |
sentence |
| 29232556 |
ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. We identify ATG4B as a substrate of mammalian sterile20-like kinase (STK) 26/MST4. MST4 phosphorylates ATG4B at serine residue 383, which stimulates ATG4B activity and increases autophagic flux. |
|
| Publications: |
1 |
| + |
ATG4B | up-regulates activity
cleavage
|
MAP1LC3C |
0.748 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-125489 |
|
|
Homo sapiens |
HEK-293 Cell, HeLa Cell |
| pmid |
sentence |
| 15187094 |
Human atg4 homologues cleave the carboxyl termini of the three human atg8 homologues, microtubule-associated protein light chain 3 (lc3), gabarap, and gate-16. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Autophagy |
| + |
ATG4B | down-regulates activity 
|
ATP synthase |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275837 |
|
|
Homo sapiens |
Colonic Cancer Cell |
| pmid |
sentence |
| 29165041 |
In this study, we identified a novel phosphorylation site at Ser34 of ATG4B induced by AKT in HCC cells.| In brief, our results demonstrate for the first time that the phosphorylation of ATG4B at Ser34 participates in the metabolic reprogramming of HCC cells via repressing mitochondrial function, which possibly results from the Ser34 phosphorylation-induced mitochondrial enrichment of ATG4B and the subsequent inhibition of F1Fo-ATP synthase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATG4B | up-regulates
cleavage
|
MAP1LC3B |
0.796 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-125449 |
|
|
Homo sapiens |
HEK-293 Cell, HeLa Cell |
| pmid |
sentence |
| 15187094 |
Human atg4 homologues cleave the carboxyl termini of the three human atg8 homologues, microtubule-associated protein light chain 3 (lc3), gabarap, and gate-16. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATG4B | up-regulates activity
cleavage
|
GABARAP |
0.856 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141929 |
|
|
in vitro |
|
| pmid |
sentence |
| 16303767 |
In vivo and in vitro biochemical analyses have shown that human atg4b is an authentic cysteine protease essential for cleavage of the c terminus of each atg8 homolog to expose the c-terminal gly |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Autophagy |
| + |
ATG4B | up-regulates activity
cleavage
|
GABARAPL2 |
0.838 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141932 |
|
|
in vitro |
|
| pmid |
sentence |
| 16303767 |
In mammals, at least three atg8 homologs, lc3, gabarap, and gate-16, have been identified (fig. 1a), all of which have structural ubiquitin folds (1416). In vivo and in vitro biochemical analyses have shown that human atg4b is an authentic cysteine protease essential for cleavage of the c terminus of each atg8 homolog to expose the c-terminal gly |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Autophagy |
3.0
ATG4B
- 
- 