Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272648 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
16601676 |
We demonstrate a mechanism for this co-regulation that involves an E3 ubiquitin ligase, EDD, which targets Paip2 for degradation. PABP depletion by RNA interference (RNAi) causes co-depletion of Paip2 protein without affecting Paip2 mRNA levels. Upon PABP knockdown, Paip2 interacts with EDD, which leads to Paip2 ubiquitination. |
|