Summary

Name UBR5
Full Name E3 ubiquitin-protein ligase UBR5
Synonyms E3 ubiquitin-protein ligase, HECT domain-containing 1, HECT-type E3 ubiquitin transferase UBR5, Hyperplastic discs protein homolog, hHYD, Progestin-induced protein | EDD, EDD1, HYD, KIAA0896
Primary ID O95071
Links - -
Type protein
Relations 9
Function E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.

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Relations

Regulator Mechanism target score
+ down-regulates quantity img/direct_inhibition.png ubiquitination RNF168 0.457
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination UBR5 0.477
Publications: 1 Organism: In Vitro
+ form complex img/form-complex.png binding EDVP 0.395
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination UBR5 0.526
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination TOPBP1 0.478
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination PCK1 0.315
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding UBR5 0.364
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination PAIP2 0.459
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination UBR5 0.2
Publications: 1 Organism: Homo Sapiens