3.0
Summary
| Name |  NABP2View Modifications |
| Full Name | SOSS complex subunit B1 |
| Synonyms | Nucleic acid-binding protein 2, Oligonucleotide/oligosaccharide-binding fold-containing protein 2B, Sensor of single-strand DNA complex subunit B1, Sensor of ssDNA subunit B1, SOSS-B1, Single-stranded DNA-binding protein 1, hSSB1 | OBFC2B, SSB1 |
| Primary ID | Q9BQ15 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ATM | up-regulates activity 
phosphorylation
|
NABP2 | 0.516 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | FBXL5 | down-regulates quantity by destabilization 
binding
|
NABP2 | 0.35 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
NABP2 | 0.297 |
| Publications: | 2 | Organism: | Homo Sapiens | |