3.0
Summary
| Name |  WDR77View Modifications |
| Full Name | Methylosome protein 50 |
| Synonyms | MEP-50, Androgen receptor cofactor p44, WD repeat-containing protein 77, p44/Mep50 | MEP50, WD45 |
| Primary ID | Q9BQA1 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334). |
phosphorylation