| + |
BMPR1A | up-regulates 
|
SOST |
0.337 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188958 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19874086 |
These results demonstrate that bmpria in osteoblasts negatively regulates endogenous bone mass and wnt/beta-catenin signaling and that this regulation may be mediated by the activities of sost and dkk1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOST | down-regulates 
|
WNT3A |
0.568 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195684 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
It has been shown that both sclerostin and dkk1 act physiologically as downstream mole-cules of bmp signaling to inhibit canonical wnt sig-naling and therefore negatively regulate bone mass |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188964 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19874086 |
It has been shown that both sclerostin and dkk1 act physiologically as downstream mole-cules of bmp signaling to inhibit canonical wnt sig-naling and therefore negatively regulate bone mass |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PTH1R | down-regulates quantity
|
SOST |
0.392 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270552 |
|
|
|
|
| pmid |
sentence |
| 28363951 |
Furthermore, PTH acts on osteocytes to suppress the expression of sclerostin, an inhibitor of canonical Wnt signaling (Li, et al. 2005; Semenov, et al. 2005)). PTH action on sclerostin is primarily through cAMP signaling (Keller and Kneissel 2005) and mediated by Myocyte enhancer factor-2 (MEF2) transcriptional regulators (Leupin, et al. 2007). Using the cAMP signaling pathway in osteoblasts, PTH also inhibits the expression of Dickkopf 1 (Dkk1) (Guo et al. 2010a), which is another Wnt pathway inhibitor |
|
| Publications: |
1 |
3.0
SOST
- 
- 