4.0
Summary
| Name |  DPH2
|
| Full Name | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 |
| Synonyms | Diphthamide biosynthesis protein 2, Diphtheria toxin resistance protein 2, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2 | DPH2L2 |
| Primary ID | Q9BQC3 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:32576952). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | DPH2 | form complex 
binding
|
2-(3-amino-3-carboxypropyl)histidine synthase complex | 0.78 |
| Publications: | 1 | Organism: | Homo Sapiens | |