| + |
DPH2 | form complex 
binding
|
2-(3-amino-3-carboxypropyl)histidine synthase complex |
0.78 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281498 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31463593 |
Diphthamide, the target of diphtheria toxin, is a post-translationally modified histidine residue found in archaeal and eukaryotic translation elongation factor 2 (EF2). In the first step of diphthamide biosynthesis, a [4Fe-4S] cluster-containing radical SAM enzyme, Dph1-Dph2 heterodimer in eukaryotes or Dph2 homodimer in archaea, cleaves S-adenosylmethionine and transfers the 3-amino-3-carboxypropyl group to EF2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DPH1 | form complex
binding
|
2-(3-amino-3-carboxypropyl)histidine synthase complex |
0.78 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281499 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31463593 |
Diphthamide, the target of diphtheria toxin, is a post-translationally modified histidine residue found in archaeal and eukaryotic translation elongation factor 2 (EF2). In the first step of diphthamide biosynthesis, a [4Fe-4S] cluster-containing radical SAM enzyme, Dph1-Dph2 heterodimer in eukaryotes or Dph2 homodimer in archaea, cleaves S-adenosylmethionine and transfers the 3-amino-3-carboxypropyl group to EF2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
2-(3-amino-3-carboxypropyl)histidine synthase complex | down-regulates activity 
chemical modification
|
EEF2 |
0.844 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281500 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31463593 |
Diphthamide, the target of diphtheria toxin, is a post-translationally modified histidine residue found in archaeal and eukaryotic translation elongation factor 2 (EF2). In the first step of diphthamide biosynthesis, a [4Fe-4S] cluster-containing radical SAM enzyme, Dph1-Dph2 heterodimer in eukaryotes or Dph2 homodimer in archaea, cleaves S-adenosylmethionine and transfers the 3-amino-3-carboxypropyl group to EF2. Dph1-Dph2 heterodimer is a non-canonical radical SAM enzyme that transfers the ACP group from SAM to EF2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
2-(3-amino-3-carboxypropyl)histidine synthase complex