| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272632 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18577513 |
Our data indicate that Nedd4-2 binds to two family members, TTYH2 and TTYH3, which contain consensus PY ((L/P)PXY) binding sites for HECT type E3 ubiquitin ligases, but not to TTYH1, which lacks this motif. Consistently, Nedd4-2 ubiquitinates both TTYH2 and TTYH3. Importantly, we have shown that endogenous TTYH2 and Nedd4-2 are binding partners and demonstrated that the TTYH2 PY motif is essential for these interactions. We have also shown that Nedd4-2-mediated ubiquitination of TTYH2 is a critical regulator of cell surface and total cellular levels of this protein. |
|
3.0
TTYH2
- 
- 
polyubiquitination