| + |
PRKD1 | up-regulates activity 
phosphorylation
|
RTKN |
0.368 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275511 |
Ser448 |
QALAKQGsLYHEMAI |
|
|
| pmid |
sentence |
| 22228765 |
Here, we show that rhotekin, an effector of RhoA GTPase, is a novel substrate of PKD. We identified Ser-435 in rhotekin as the potential site targeted by PKD in vivo. Expression of a phosphomimetic S435E rhotekin mutant resulted in an increase of endogenous active RhoA GTPase levels. Phosphorylation of rhotekin by PKD2 modulates the anchoring of the RhoA in the plasma membrane. |
|
| Publications: |
1 |
| + |
RTKN | down-regulates 
|
SEPTIN9 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-138578 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16007136 |
We identified rhotekin, a downstream effector for rho, as a candidate regulator organizing septin structures through filament disruption. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RTKN
- 
- 