4.0
Summary
| Name |  TCHP
|
| Full Name | Trichoplein keratin filament-binding protein |
| Synonyms | Protein TCHP, Mitochondrial protein with oncostatic activity, Mitostatin, Tumor suppressor protein | |
| Primary ID | Q9BT92 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701). Is a negative regulator of ciliogenesis (PubMed:25270598). {ECO:0000269|PubMed:15731013, ECO:0000269|PubMed:18931701, ECO:0000269|PubMed:25270598}. |
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polyubiquitination