4.0
Summary
| Name |  CRB3
|
| Full Name | Protein crumbs homolog 3 |
| Synonyms | CRUM3_HUMAN |
| Primary ID | Q9BUF7 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Involved in the establishment of cell polarity in mammalian epithelial cells (PubMed:12771187, PubMed:14718572). Regulates the morphogenesis of tight junctions (PubMed:12771187, PubMed:14718572). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CRB3 | up-regulates 
binding
|
AMOT/MPP5/INADL/LIN7C | 0.538 |
| Publications: | 1 | Organism: | Mus Musculus | |