Summary

Name TMEM147
Full Name BOS complex subunit TMEM147
Synonyms Protein NIFIE 14, Transmembrane protein 147 |
Primary ID Q9BVK8
Links - -
Type protein
Relations 3
Function Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane (PubMed:21056967). Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity (PubMed:21056967). Regulates LBR localization to the nucleus inner membrane (PubMed:32694168).

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Relations

Regulator Mechanism target score ℹ
+ TMEM147form complex img/form-complex.png binding BOS complex, NOMO3 variant 0.435
Publications: 1 Organism: Homo Sapiens
+ TMEM147form complex img/form-complex.png binding BOS complex, NOMO1 variant 0.433
Publications: 1 Organism: Homo Sapiens
+ TMEM147form complex img/form-complex.png binding BOS complex, NOMO2 variant 0.499
Publications: 1 Organism: Homo Sapiens